This study was aimed at examining the perceptions regarding AD among a representative sample of 632 adult (18+ years old) Israeli people. Since gender is one factor that may influence lay persons’ worry and concern about developing AD, this study focused on examining gender differences in these perceptions. The results showed that males and the females had no statistically differences in their awareness of AD. This awareness may be attributed to growing exposure of the disease in the media as well as to the increased efforts of AD associations worldwide to increase the public’s awareness of the illness. However, male and female participants in the study perceived their risk of developing AD as minimal. Regarding gender differences, a higher percentage of females than males in the study reported perceived susceptibility, worry, fear, and knowledge about AD. These findings are probably due to women’s caregiving role in our society, that may raise their awareness of the risk of illness, or to the higher prevalence of AD among women, who account for almost two-thirds of Americans with AD and are therefore at greater risk. Another possible reason might be related more to personality differences between genders than to specific characteristics of the disease. These results highlight the need to develop gender-specific interventions and educational programs to improve the knowledge and awareness of the general public about AD, and especially among men..