Lorenzini foundation Centro studi Lorenzini foundation Centro studi


Working Group Coordinators
PierGiorgio Crosignani (Milan)
Adriana Maggi (Milan)

PierGiorgio Crosignani (clinical issues)
Professor of Obstetrics and Gynaecology
Fondazione IRCCS Policlinico
Via M. Fanti, 6
20122 Milan, Italy
e-mail: piergiorgio.crosignani@unimi.it
Web: http://www.policlinico.mi.it

Adriana Maggi (research)
Centre of Excellence on Neurodegenerative Diseases (CEND) and
Department of Pharmacological Sciences
University of Milan
Via Balzaretti 9
20133 Milan, Italy
e-mail: adriana.maggi@unimi.it
Web: http://users.unimi.it/~spharm/isf.html

Purpose - clinical issues:
The proportion of women living past the age of menopause has tripled during the last century, and is expected to increase steadily in the future, therefore women in much of the developed world live one-half their adult lives postmenopause.
The menopause offers the health care provider an opportunity to assess each woman's health and to suggest specific prevention measures, and in particular positive life style changes that have been proved to prevent ageing related diseases.
Benefits and risks of hormone therapy in menopausal women continue to be assessed while new nonhormone therapies offer alternative options for the prevention of the common menopausal conditions.

Purpose - research in animal models:
Basic research in the field of women aging and particularly on the study of hormonal effects are still object of heated discussion for a number of reasons:

  1. The biology of sex hormones in organs other than those involved in sexual functions are still largely unknown.
  2. In the absence of an in depth knowledge of progesterone and estrogen and their receptors in non reproductive organs the generation of drugs for a safe therapy of the pathologies associated to menopause is seriously held back.
  3. Unless we use primates, we lack of animal models which undergo natural menopause, this hampers significantly the studies done in rodents and other experimental animals.

The aim of the group is therefore to strengthen research on the basic mechanisms of women aging and on the role of sex hormones and cognate receptor in non reproductive organs with an emphasis on nervous, immune, cardiovascular, skeletal systems.

References (for clinical issues)
TannenR.L., Weiner M.G., Xie D., et al. Perspective on hormone replacement therapy: the women's Health Initiative and new observational studies sampling the overall population. Fertil. Steril., 90, 258-264, 2008.
Jarvinen T., Sievanen H., Khan K.M., et al. Shifting the focus in fracture prevention from osteoporosis to falls. BMJ, 336, 124, 2008.

Members of the menopause working group (clinical issues):

Silvano Adami (Osteoporosis)
Division of Bones and Joints Rehabilitation
Centro Ospedaliero Clinicizzato
Valeggio sul Mincio
E-mail: silvano.adami@univr.it

Andrea Giustina (Endocrinology)
Department of Medical and Surgical Sciences
University of Brescia

Secondo Guaschino (Gynaecology)
Director Obstetrics and Gynaecology Department
University of Trieste
IRCCS Burlo Garofolo Hospital
Via dell'Istria. 65/1 34137
E-mail: guaschin@burlo.trieste.it

Carlo La Vecchia (Epidemiology)
Mario Negri Institute
Via Eritrea, 62
E-mail: carlo.lavecchia@unimi.it

Antonio Lanzone (Gynaecology and Endocrinology)
Department of Obstetrics and Gynecology
Agostino Gemelli Hospital
L.go A. Gemelli, 8
00100 ROME – ITALY
E-mail: alanzone@rm.unicatt.it

Carmine Nappi (Gynaecology)
Department of Obstetrics and Gynaecology
Policlinico Federico II
E-mail: nappi@unina.it

Aldo Pinchera (Endocrinology)
Professor of Endocrinology
Director Medical School in Endocrinology
University of Pisa
Via Paradisa, 2
56124 PISA – ITALY
E-mail: a.pinchera@endoc.med.unipi.it

Giuseppe Rosano (Cardiology)
Department of Medical Sciences
Cardiovascular Research Unit
San Raffaele Hospital
Via della Pisana 234,
00163 ROME - ITALY
E-mail: giuseppe.rosano@sanraffaele.it

Annibale Volpe (Gynaecology)
Department “Integrato Materno Infantile”
University of Modena
L.go del Pozzo, 71
E-mail: volpe.annibale@unimo.it